Nuclear Technology & Radiation Protection Journal


NT & RP Journal	CALCULATION OF ABSORBED DOSE DUE TO THE ⁹⁰Y-DOTATOC PEPTIDE RECEPTOR RADIONUCLIDE THERAPY BY MCNP5/X
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Vol. XXXIII, No. 4, Pp. 325-417 December 2018 UDC 621.039+614.876:504.06 ISSN 1451-3994 Back to Contents	Pages: 380-385 Authors: Marija Ž. Jeremić, Milovan D. Matović, Suzana B. Pantović, Dragoslav R. Nikezić, and Dragana Ž. Krstić Abstract Strong beta emitters, like ⁹⁰Y, ¹⁷⁷Lu labelled peptide, are used for treatment of neuroendocrine tumours where there is a good expression of somatostatin receptors. In this work, MCNP5/X computer software and ORNL human phantoms were used to calculate absorbed dose due to 90Y labelled DOTATOC in the peptide receptor radionuclide therapy. Tumour was considered as a sources of beta radiation and represented as a sphere with diameter of 1-4 cm and 5 cm in liver, pancreas, and lungs. Results are expressed as absorbed dose per unit of cumulated activity, S – value in units mGy·(MBq·s)^-1. The far largest dose is in tumour itself, then in organ which contains the tumour. Doses in other organs, where the metastasis are the most frequent, due to the bremsstrahlung radiation, are much smaller and could be neglected. The largest dose, 8.66·10^-3 mGy·(MBq·s)^-1 was obtained for tumour with size of 3 cm. Key words: Monte Carlo simulation, ⁹⁰Y-DOTATOC, radionuclide therapy, dosimetry FULL PAPER IN PDF FORMAT (4.61 MB)
Vinča Institute of Nuclear Sciences :: Designed by milas :: July 2007 Operated by acapanic :: Last updated on February, 2019

Pages: 380-385

Authors: Marija Ž. Jeremić, Milovan D. Matović, Suzana B. Pantović, Dragoslav R. Nikezić,
and Dragana Ž. Krstić

Abstract

Strong beta emitters, like ⁹⁰Y, ¹⁷⁷Lu labelled peptide, are used for treatment of neuroendocrine tumours where there is a good expression of somatostatin receptors. In this work, MCNP5/X computer software and ORNL human phantoms were used to calculate absorbed dose due to 90Y labelled DOTATOC in the peptide receptor radionuclide therapy. Tumour was considered as a sources of beta radiation and represented as a sphere with diameter of 1-4 cm and 5 cm in liver, pancreas, and lungs. Results are expressed as absorbed dose per unit of cumulated activity, S – value in units mGy·(MBq·s)^-1. The far largest dose is in tumour itself, then in organ which contains the tumour. Doses in other organs, where the metastasis are the most frequent, due to the bremsstrahlung radiation, are much smaller and could be neglected. The largest dose, 8.66·10^-3 mGy·(MBq·s)^-1 was obtained for tumour with size of 3 cm.

Key words: Monte Carlo simulation, ⁹⁰Y-DOTATOC, radionuclide therapy, dosimetry

FULL PAPER IN PDF FORMAT (4.61 MB)